About Us
Our research is mainly on the development of eukaryotic genome and RNA editing tools, with the focus on high-throughput functional genomics. The combination of forward and reverse genetic means is employed, often in a high-throughput fashion, for the identification of host genes important for host response during microbial infections or tumorigenesis.
致力于发展基因编辑技术、功能基因组学以及基因治疗；在此基础上研究癌症、感染等重大疾病发生机制，为发展高效治疗手段提供新的药物靶点和思路。
News
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祝贺牛煦然同学获得2024-2025学年校长奖学金 2024-06-13
2024年6月，根据《北京大学博士研究生校长奖学金管理办法》及相关规定要求，经过生命科学学院评审委员会组织的答辩和评审工...
Areas of Focus
Genome and RNA editing
We are interested in developing novel genome and RNA editing tools and optimizing current ed...
High-throughput functional genomics
We are developing variety of high-throughput screening platforms based on genome and RNA editing ...
Cancer and infection
By combining high-throughput screening and sequencing, we aim to study mechanisms underlying canc...
People
Publications
- $article.getProperty("laiyuan") Streamlined process for effective and strand-selective mitochondrial base editing using mitoBEs. $article.getProperty("banben")
- $article.getProperty("laiyuan") Massively parallel interrogation of human functional variants modulating cancer immunosurveillance. $article.getProperty("banben")
- $article.getProperty("laiyuan") Unsynchronized butyrophilin molecules dictate cancer cell evasion of Vγ9Vδ2 T-cell killing. $article.getProperty("banben")
- $article.getProperty("laiyuan") CEA cell adhesion molecule 5 enriches functional human hematopoietic stem cells capable of long-term multi-lineage engraftment. $article.getProperty("banben")
- $article.getProperty("laiyuan") Unbiased interrogation of functional lysine residues in human proteome. $article.getProperty("banben")
- $article.getProperty("laiyuan") Utilizing AAV-mediated LEAPER 2.0 for programmable RNA editing in non-human primates and nonsense mutation correction in humanized Hurler syndrome mice. $article.getProperty("banben")
- $article.getProperty("laiyuan") Strand-selective base editing of human mitochondrial DNA using mitoBEs. $article.getProperty("banben")
- $article.getProperty("laiyuan") CRISPR-free, strand-selective mitochondrial DNA base editing using a nickase. $article.getProperty("banben")
- $article.getProperty("laiyuan") DddA homolog search and engineering expand sequence compatibility of mitochondrial base editing. $article.getProperty("banben")
- $article.getProperty("laiyuan") Human FcRn Is a Two-in-One Attachment-Uncoating Receptor for Echovirus 18. $article.getProperty("banben")
- $article.getProperty("laiyuan") Regulatory elements can be essential for maintaining broad chromatin organization and cell viability. $article.getProperty("banben")
- $article.getProperty("laiyuan") Circular RNA Vaccines against SARS-CoV-2 and Emerging Variants. $article.getProperty("banben")
- $article.getProperty("laiyuan") Gene editing: from technologies to applications in research and beyond. $article.getProperty("banben")
- $article.getProperty("laiyuan") Gene editing and its applications in biomedicine. $article.getProperty("banben")
- $article.getProperty("laiyuan") Engineered circular ADAR-recruiting RNAs increase the efficiency and fidelity of RNA editing in vitro and in vivo. $article.getProperty("banben")
- $article.getProperty("laiyuan") Noncoding loci without epigenomic signals can be essential for maintaining global chromatin organization and cell viability. $article.getProperty("banben")
- $article.getProperty("laiyuan") Sensing of cytoplasmic chromatin by cGAS activates innate immune response in SARS-CoV-2 infection. $article.getProperty("banben")
- $article.getProperty("laiyuan") Genome-wide CRISPR activation screen identifies candidate receptors for SARS-CoV-2 entry. $article.getProperty("banben")
- $article.getProperty("laiyuan") Low-density lipoprotein receptor-related protein 1 is a CROPs-associated receptor for Clostridioides difficile toxin B. $article.getProperty("banben")
- $article.getProperty("laiyuan") Genome-wide interrogation of gene functions through base editor screens empowered by barcoded sgRNAs. $article.getProperty("banben")
- $article.getProperty("laiyuan") Genome-wide CRISPR activation screen identifies novel receptors for SARS-CoV-2 entry. $article.getProperty("banben")
- $article.getProperty("laiyuan") Circular RNA Vaccines against SARS-CoV-2 and Emerging Variants. $article.getProperty("banben")
- $article.getProperty("laiyuan") TRIM26 is a critical host factor for HCV replication and contributes to host tropism. $article.getProperty("banben")
- $article.getProperty("laiyuan") Activation and evasion of type I interferon responses by SARS-CoV-2. $article.getProperty("banben")
- $article.getProperty("laiyuan") Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients. $article.getProperty("banben")
- $article.getProperty("laiyuan") Reply to: Fitness effects of CRISPR/Cas9-targeting of long noncoding RNA genes. $article.getProperty("banben")
- $article.getProperty("laiyuan") Structural Insights into the Specific Recognition of 5-methylcytosine and 5-hydroxymethylcytosine by TAL Effectors. $article.getProperty("banben")
- $article.getProperty("laiyuan") PASTMUS: mapping functional elements at single amino acid resolution in human cells. $article.getProperty("banben")
- $article.getProperty("laiyuan") Programmable RNA editing by recruiting endogenous ADAR using engineered RNAs. $article.getProperty("banben")
- $article.getProperty("laiyuan") Human Neonatal Fc Receptor Is the Cellular Uncoating Receptor for Enterovirus B. $article.getProperty("banben")
- $article.getProperty("laiyuan") In vivo ways to unveil off-targets. $article.getProperty("banben")
- $article.getProperty("laiyuan") Adopt a moratorium on heritable genome editing. $article.getProperty("banben")
- $article.getProperty("laiyuan") Guide RNAs with embedded barcodes boost CRISPR-pooled screens. $article.getProperty("banben")
- $article.getProperty("laiyuan") CRISPR twins: a condemnation from Chinese academic societies. $article.getProperty("banben")
- $article.getProperty("laiyuan") Interrogating the noncoding genome in a high-throughput fashion. $article.getProperty("banben")
- $article.getProperty("laiyuan") Gene editing technology and its research progress in China. $article.getProperty("banben")
- $article.getProperty("laiyuan") Genome-wide screening for functional long noncoding RNAs in human cells by Cas9 targeting of splice sites. $article.getProperty("banben")
- $article.getProperty("laiyuan") PrePAIRing Cas9s for screening success. $article.getProperty("banben")
- $article.getProperty("laiyuan") A surrogate reporter system for multiplexable evaluation of CRISPR/Cas9 in targeted mutagenesis. $article.getProperty("banben")
- $article.getProperty("laiyuan") Attachment and Postattachment Receptors Important for Hepatitis C Virus Infection and Cell-to-Cell Transmission. $article.getProperty("banben")
- $article.getProperty("laiyuan") Glucosyltransferase Activity of Clostridium difcile Toxin B Triggers Autophagy-mediated Cell Growth Arrest. $article.getProperty("banben")
- $article.getProperty("laiyuan") Live visualization of genomic loci with BiFC-TALE. $article.getProperty("banben")
- $article.getProperty("laiyuan") Deciphering TAL effectors for 5-methylcytosine and 5-hydroxymethylcytosine recognition. $article.getProperty("banben")
- $article.getProperty("laiyuan") Painting a specific chromosome with CRISPR/Cas9 for live-cell imaging. $article.getProperty("banben")
- $article.getProperty("laiyuan") Genome-Wide CRISPR/Cas9 Screening for High-Throughput Functional Genomics in Human Cells. $article.getProperty("banben")
- $article.getProperty("laiyuan") Questions about NgAgo. $article.getProperty("banben")
- $article.getProperty("laiyuan") Long-term dual-color tracking of genomic loci by modified sgRNAs of the CRISPR/Cas9 system. $article.getProperty("banben")
- $article.getProperty("laiyuan") Assembly of Customized TAL Effectors Through Advanced ULtiMATE System. $article.getProperty("banben")
- $article.getProperty("laiyuan") Mapping regulatory elements. $article.getProperty("banben")
- $article.getProperty("laiyuan") Simultaneous generation of multi-gene knockouts in human cells. $article.getProperty("banben")
- $article.getProperty("laiyuan") Making better CRISPR libraries. $article.getProperty("banben")
- $article.getProperty("laiyuan") Genome-scale deletion screening of human long non-coding RNAs using a paired-guide RNA CRISPR-Cas9 library. $article.getProperty("banben")
- $article.getProperty("laiyuan") Divergent roles of BECN1 in LC3 lipidation and autophagosomal function. $article.getProperty("banben")
- $article.getProperty("laiyuan") High-throughput screens in mammalian cells using the CRISPR-Cas9 system. $article.getProperty("banben")
- $article.getProperty("laiyuan") A Dual-Reporter System for Real-Time Monitoring and High-throughput CRISPR/Cas9 Library Screening of the Hepatitis C Virus. $article.getProperty("banben")
- $article.getProperty("laiyuan") A microfluidic live cell assay to study anthrax toxin induced cell lethality assisted by conditioned medium. $article.getProperty("banben")
- $article.getProperty("laiyuan") Chondroitin sulfate proteoglycan 4 functions as the cellular receptor for Clostridium difficile toxin B. $article.getProperty("banben")
- $article.getProperty("laiyuan") Bidirectional effect of Wnt signaling antagonist DKK1 on the modulation of anthrax toxin uptake. $article.getProperty("banben")
- $article.getProperty("laiyuan") Complete decoding of TAL effectors for DNA recognition. $article.getProperty("banben")
- $article.getProperty("laiyuan") High-throughput screening of a CRISPR/Cas9 library for functional genomics in human cells. $article.getProperty("banben")
- $article.getProperty("laiyuan") ULtiMATE System for Rapid Assembly of CustomizedTAL Effectors. $article.getProperty("banben")
Join Us
Contact
- Email：weilab@pku.edu.cn
- Address：Rm604, 603, Jinguang Life Science Bldg, BIOPIC 209
School of Life Sciences, Peking University
No.5 Yiheyuan Road, Beijing
P.R. China 100871
